dc.contributor.author |
Kurtoğlu, Emel |
|
dc.contributor.author |
Altunkaynak, Berrin Zuhal |
|
dc.contributor.author |
Alkan, Işınsu |
|
dc.contributor.author |
Özdemir, Ayşe |
|
dc.contributor.author |
Altun, Gamze |
|
dc.contributor.author |
Kökçü, Arif |
|
dc.contributor.author |
Kaplan, Süleyman |
|
dc.date.accessioned |
2022-06-13T11:41:48Z |
|
dc.date.available |
2022-06-13T11:41:48Z |
|
dc.date.issued |
2015 |
|
dc.identifier.citation |
Kurtoglu E, Altunkaynak BZ, Aydin I, Ozdemir AZ, Altun G, Kokcu A, Kaplan S. Role of vascular endothelial growth factor and placental growth factor expression on placenta structure in pre-eclamptic pregnancy. J Obstet Gynaecol Res. 2015 Oct;41(10):1533-40. doi: 10.1111/jog.12751. Epub 2015 Jul 14. PMID: 26177586. |
tr_TR |
dc.identifier.uri |
http://hdl.handle.net/20.500.11787/6679 |
|
dc.description.abstract |
Aim: Pre-eclampsia is a hypertensive disease that is characterized by high blood pressure and proteinuria after 20 gestational weeks and complicates 3-8% of all pregnancies. It is classified as either mild or severe pre-eclampsia according to severity, and the aim of this study was to investigate the structural differences between these two classifications.
Methods: Placenta samples were collected from 68 women who underwent cesarean delivery. Total volume of villi and numerical density of vascular endothelial growth factor (VEGF)- and placental growth factor (PIGF)-positive cells were estimated on stereology and evaluated using one-way ANOVA.
Results: There was no significantly difference in total villi volumes between the groups (P > 0.05). In contrast, on immunohistochemistry, the numerical density of VEGF-positive cells in severe pre-eclampsia was significantly different to the control and mild pre-eclampsia groups (P<0.05). Additionally, the numerical density of PIGF-positive cells in the mild and severe pre-eclampsia group was significantly higher than in the control group (P<0.01).
Conclusion: There is no relationship between villi volume and pre-eclampsia, although growth factors play a role in placental changes. The present results were supported by histopathology and several studies in the literature. |
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dc.language.iso |
eng |
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dc.publisher |
factor and placental growth factor expression on placenta structure in pre-eclamptic pregnancy. JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH |
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dc.relation.isversionof |
10.1111/jog.12751 |
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dc.rights |
info:eu-repo/semantics/restrictedAccess |
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dc.subject |
Mild pre-eclampsia |
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dc.subject |
Placental growth factor |
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dc.subject |
Severe pre-eclampsia |
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dc.subject |
Stereology |
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dc.subject |
Vascular endothelial growth factor |
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dc.title |
Role of vascular endothelial growth factor and placental growth factor expression on placenta structure in pre-eclamptic pregnancy |
tr_TR |
dc.type |
article |
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dc.contributor.department |
Nevşehir Hacı Bektaş Veli Üniversitesi/diş hekimliği fakültesi/temel bilimler bölümü/temel tıp bilimleri anabilim dalı |
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dc.contributor.authorID |
310749 |
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dc.identifier.volume |
41 |
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dc.identifier.issue |
10 |
tr_TR |
dc.identifier.startpage |
1533 |
tr_TR |
dc.identifier.endpage |
1540 |
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