Role of vascular endothelial growth factor and placental growth factor expression on placenta structure in pre-eclamptic pregnancy

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dc.contributor.author Kurtoğlu, Emel
dc.contributor.author Altunkaynak, Berrin Zuhal
dc.contributor.author Alkan, Işınsu
dc.contributor.author Özdemir, Ayşe
dc.contributor.author Altun, Gamze
dc.contributor.author Kökçü, Arif
dc.contributor.author Kaplan, Süleyman
dc.date.accessioned 2022-06-13T11:41:48Z
dc.date.available 2022-06-13T11:41:48Z
dc.date.issued 2015
dc.identifier.citation Kurtoglu E, Altunkaynak BZ, Aydin I, Ozdemir AZ, Altun G, Kokcu A, Kaplan S. Role of vascular endothelial growth factor and placental growth factor expression on placenta structure in pre-eclamptic pregnancy. J Obstet Gynaecol Res. 2015 Oct;41(10):1533-40. doi: 10.1111/jog.12751. Epub 2015 Jul 14. PMID: 26177586. tr_TR
dc.identifier.uri http://hdl.handle.net/20.500.11787/6679
dc.description.abstract Aim: Pre-eclampsia is a hypertensive disease that is characterized by high blood pressure and proteinuria after 20 gestational weeks and complicates 3-8% of all pregnancies. It is classified as either mild or severe pre-eclampsia according to severity, and the aim of this study was to investigate the structural differences between these two classifications. Methods: Placenta samples were collected from 68 women who underwent cesarean delivery. Total volume of villi and numerical density of vascular endothelial growth factor (VEGF)- and placental growth factor (PIGF)-positive cells were estimated on stereology and evaluated using one-way ANOVA. Results: There was no significantly difference in total villi volumes between the groups (P > 0.05). In contrast, on immunohistochemistry, the numerical density of VEGF-positive cells in severe pre-eclampsia was significantly different to the control and mild pre-eclampsia groups (P<0.05). Additionally, the numerical density of PIGF-positive cells in the mild and severe pre-eclampsia group was significantly higher than in the control group (P<0.01). Conclusion: There is no relationship between villi volume and pre-eclampsia, although growth factors play a role in placental changes. The present results were supported by histopathology and several studies in the literature. tr_TR
dc.language.iso eng tr_TR
dc.publisher factor and placental growth factor expression on placenta structure in pre-eclamptic pregnancy. JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH tr_TR
dc.relation.isversionof 10.1111/jog.12751 tr_TR
dc.rights info:eu-repo/semantics/restrictedAccess tr_TR
dc.subject Mild pre-eclampsia tr_TR
dc.subject Placental growth factor tr_TR
dc.subject Severe pre-eclampsia tr_TR
dc.subject Stereology tr_TR
dc.subject Vascular endothelial growth factor tr_TR
dc.title Role of vascular endothelial growth factor and placental growth factor expression on placenta structure in pre-eclamptic pregnancy tr_TR
dc.type article tr_TR
dc.contributor.department Nevşehir Hacı Bektaş Veli Üniversitesi/diş hekimliği fakültesi/temel bilimler bölümü/temel tıp bilimleri anabilim dalı tr_TR
dc.contributor.authorID 310749 tr_TR
dc.identifier.volume 41 tr_TR
dc.identifier.issue 10 tr_TR
dc.identifier.startpage 1533 tr_TR
dc.identifier.endpage 1540 tr_TR


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