The effect of (3-Mercaptopropyl)trimethoxysilane (MPS) coating on the genetic detection performance of quartz crystal microbalance-dissipation (QCM-D) biosensor: novel Intact double-layered surface modification on QCM-D

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dc.contributor.author Soysaldı, Furkan
dc.contributor.author Soylu, Mehmet Çağrı
dc.date.accessioned 2022-06-20T14:17:08Z
dc.date.available 2022-06-20T14:17:08Z
dc.date.issued 2021-06
dc.identifier.uri http://dx.doi.org/10.1002/slct.202100739
dc.identifier.uri http://hdl.handle.net/20.500.11787/7222
dc.description.abstract Biosensor's ability depends on both platform performance and surface modification. In mass sensitive biosensors, a stable coating with molecular structural dynamism increases sensitivity. Also, its orientation and smoothness directly affect the performance of cross-linker molecules and receptors. In this study, the performance of intact double-layered (ID) coating used on QCM-D for the first time in DNA detection of MPS was investigated. The sensitivity of the QCM-D with ID-MPS was compared to the uncoated. At the concentrations of 10(10) and 10(13) copies/mL, the method with ID-MPS was approximately 6.4 times more sensitive. A shift of 1.22(+/- 0.42) Hz was observed at the detection limit at 10(8) copies/mL, while it was 0.19(+/- 0.05) Hz in the negative control. Thus, a signal-to-noise-ratio greater than 3, which is a measure of signal quality in biosensors, was exceeded with a ratio of 3.33, and it was shown that the detection signal at the sensitivity limit was sufficient. In addition, the two methods were compared visually with atomic force microscopy in terms of the amount and distribution of captured molecules, and it was determined that the ID-MPS was more efficient. tr_TR
dc.language.iso eng tr_TR
dc.publisher ChemistrySelect tr_TR
dc.relation.isversionof 10.1002/slct.202100739 tr_TR
dc.rights info:eu-repo/semantics/closedAccess tr_TR
dc.subject Biosensor tr_TR
dc.subject DNA Detection tr_TR
dc.subject QCM tr_TR
dc.title The effect of (3-Mercaptopropyl)trimethoxysilane (MPS) coating on the genetic detection performance of quartz crystal microbalance-dissipation (QCM-D) biosensor: novel Intact double-layered surface modification on QCM-D tr_TR
dc.type article tr_TR
dc.relation.journal ChemistrySelect tr_TR
dc.contributor.department NEVŞEHİR HACI BEKTAŞ VELİ ÜNİVERSİTESİ/MESLEK YÜKSEKOKULU/ELEKTRONİK VE OTOMASYON BÖLÜMÜ/BİYOMEDİKAL CİHAZ TEKNOLOJİSİ PR. tr_TR
dc.contributor.authorID 260373 tr_TR
dc.contributor.authorID 197095 tr_TR
dc.identifier.volume 6 tr_TR
dc.identifier.issue 24 tr_TR
dc.identifier.startpage 6056 tr_TR
dc.identifier.endpage 6062 tr_TR


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